Abstract |
Bartonella henselae is the causative agent of cat-scratch disease and other disorders, including hepatosplenic granulomatosis. This infection has only rarely been reported after solid organ transplantation, where it can mimic the more common post-transplant lymphoproliferative disease. Here we present a case of asymptomatic B. henselae hepatic and lymph nodal granulomatosis in a pediatric patient who had received orthotopic liver transplant 2 months before; we hypothesize that the causative agent was transmitted from the donor. This infection developed early in the post-transplant period; the disease involved only the graft liver and the regional lymph nodes, and the patient did not have a cat or any history of contact, scratches, or bites by a cat. In our patient this infection resolved successfully with a combination of 2 associated antibiotics and reduction of immunosuppressive therapy.
|
Authors | C Scolfaro, F Mignone, F Gennari, A Alfarano, A Veltri, R Romagnoli, M Salizzoni |
Journal | Transplant infectious disease : an official journal of the Transplantation Society
(Transpl Infect Dis)
Vol. 10
Issue 6
Pg. 431-3
(Dec 2008)
ISSN: 1399-3062 [Electronic] Denmark |
PMID | 18651873
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Anti-Infective Agents
- Antibodies, Bacterial
- Immunosuppressive Agents
- RNA, Bacterial
- RNA, Ribosomal, 16S
- RNA, Ribosomal, 23S
- Trimethoprim, Sulfamethoxazole Drug Combination
- Azithromycin
- Amikacin
- Tacrolimus
|
Topics |
- Amikacin
(therapeutic use)
- Anti-Infective Agents
(therapeutic use)
- Antibodies, Bacterial
(blood)
- Azithromycin
(therapeutic use)
- Bartonella henselae
(isolation & purification)
- Cat-Scratch Disease
(diagnosis, drug therapy, etiology, transmission)
- Child
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Liver
(diagnostic imaging, microbiology, pathology)
- Liver Neoplasms
(diagnosis, drug therapy, etiology, microbiology)
- Liver Transplantation
(adverse effects)
- Lymph Nodes
(diagnostic imaging, microbiology, pathology)
- Lymphomatoid Granulomatosis
(diagnosis, drug therapy, etiology, microbiology)
- Male
- Postoperative Complications
(diagnosis, etiology, microbiology)
- RNA, Bacterial
(analysis)
- RNA, Ribosomal, 16S
(analysis)
- RNA, Ribosomal, 23S
(analysis)
- Tacrolimus
(administration & dosage)
- Tissue Donors
- Transplants
(microbiology)
- Treatment Outcome
- Trimethoprim, Sulfamethoxazole Drug Combination
(therapeutic use)
- Ultrasonography
|