Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs.

Abstract

BACKGROUND:

It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed.

AIM:

To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).

METHODS:

We recorded the numbers and details of all patients presenting in our region of Scotland with perforation between 1997 and 2006 including demography, drug usage and 30-day mortality.

RESULTS:

In subjects aged >65 years, the annual incidence of perforation was 32.7 per 10(5) of the age-specific population, of whom 10.7 per 10(5) were taking low-dose aspirin and 12.0 taking NSAIDs. These were all significantly higher (P < 0.001) than the corresponding incidence in subjects aged < or =65 years (6.6 per 10(5) overall, 1.1 taking aspirin and 2.5 taking NSAIDs). There was an increasing trend with time in the number of patients taking NSAIDs (chi(2) = 4.57, P = 0.03). Using univariate analysis, 30-day mortality was associated with aspirin [odds ratio, 2.32 (95% C.I., 1.20-4.47), P = 0.01] but not with NSAIDs. The strongest predictors of mortality were increasing age and comorbidity.

CONCLUSIONS:

Perforation remains common in elderly patients including users of NSAIDs and aspirin. Early mortality is also noted in association with increasing age and comorbidity, but not independently with drug intake.

• Authors: A S Taha, W J Angerson, R Prasad, C McCloskey, D Gilmour, C G Morran
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 28 Issue 7 Pg. 878-85 (Oct 01 2008) ISSN: 1365-2036 [Electronic] England
• PMID: 18644010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Fibrinolytic Agents
• Aspirin

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aspirin (therapeutic use)
• Comorbidity
• Drug Administration Schedule
• Female
• Fibrinolytic Agents (therapeutic use)
• Humans
• Incidence
• Male
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Peptic Ulcer (mortality)
• Peptic Ulcer Perforation (complications, epidemiology, mortality)
• Retrospective Studies
• Risk Factors
• Scotland (epidemiology)
• Time