[Purulent corneal melting secondary to multidrug-resistant Fusarium oxysporum aggravated by topical corticosteroid therapy].

Abstract

Keratomycosis is a rare sight-threatening infection of the cornea. Predisposing factors in its pathogenesis are corneal trauma, mostly of plant origin, contact lenses, and overuse of topical corticosteroids. We report a case of a 44-year-old woman, with no ophthalmologic history, who developed severe keratitis 7 days after beginning topical therapy with a corticosteroid and antibiotic. Microbiological analysis revealed Fusarium oxysporum keratitis. Despite aggressive antifungal therapy with Voriconazole and Amphotericin B, she required a penetrating keratoplasty for impending corneal perforation. A second keratoplasty was performed because of corneal-transplant rejection after 6 months. There was no recurrence of Fusarium infection.

• Authors: A Sauer, F Abry, B Lhermitte, E Candolfi, C Speeg-Schatz, T Bourcier
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 31 Issue 5 Pg. 534.e1-5 (May 2008) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Fonte purulente de la cornée secondaire à une infection à Fusarium oxysporum polyrésistant favorisée par une corticothérapie topique.
• PMID: 18641575 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Anti-Bacterial Agents
• Antifungal Agents

Topics

• Adrenal Cortex Hormones (adverse effects)
• Adult
• Anti-Bacterial Agents (adverse effects)
• Antifungal Agents (therapeutic use)
• Corneal Diseases (drug therapy, microbiology, surgery)
• Female
• Fusarium (drug effects)
• Humans
• Keratoplasty, Penetrating
• Mycoses (drug therapy, surgery)
• Reoperation
• Treatment Outcome