HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Huntington's disease: degradation of mutant huntingtin by autophagy.

Abstract
Autophagy is a nonspecific bulk degradation pathway for long-lived cytoplasmic proteins, protein complexes, or damaged organelles. This process is also a major degradation pathway for many aggregate-prone, disease-causing proteins associated with neurodegenerative disorders, such as mutant huntingtin in Huntington's disease. In this review, we discuss factors regulating the degradation of mutant huntingtin by autophagy. We also report the growing list of new drugs/pathways that upregulate autophagy to enhance the clearance of this mutant protein, as autophagy upregulation may be a tractable strategy for the treatment of Huntington's disease.
AuthorsSovan Sarkar, David C Rubinsztein
JournalThe FEBS journal (FEBS J) Vol. 275 Issue 17 Pg. 4263-70 (Sep 2008) ISSN: 1742-464X [Print] England
PMID18637946 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • HTT protein, human
  • Huntingtin Protein
  • Lithium Compounds
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Inositol
  • Trehalose
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Sirolimus
Topics
  • Autophagy (drug effects)
  • Humans
  • Huntingtin Protein
  • Huntington Disease (genetics, immunology, metabolism)
  • Inositol (antagonists & inhibitors)
  • Lithium Compounds (pharmacology)
  • Mutation
  • Nerve Tissue Proteins (genetics, metabolism)
  • Nuclear Proteins (genetics, metabolism)
  • Protein Kinases (metabolism)
  • Sirolimus (pharmacology)
  • TOR Serine-Threonine Kinases
  • Trehalose (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: