Clinical efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of localized prostate cancer.

Abstract

BACKGROUND:

The objective of this study was to evaluate the efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the detection of prostate cancer.

MATERIALS AND METHODS:

The experimental group consisted of 20 patients with localized prostate cancer who underwent radical prostatectomy. The sensitivity, positive predictive value and accuracy of the detection of prostate cancer in the 12 sections of the peripheral zone were calculated for prostate biopsy alone, 1H-MRS alone and the combination of these methods, respectively.

RESULTS:

The sensitivity, the positive predictive value, and the accuracy of the preoperative diagnosis of prostate cancer were 43.7%, 68.9% and 54.6%, respectively, with prostate biopsy alone; 60.6%, 87.8% and 71.4% with 1H-MRS alone; and 88.7%, 88.7% and 87.4% with the combination of biopsy and 1H-MRS, respectively. Combined use of biopsy and 1H-MRS significantly improved the sensitivity, positive predictive value and accuracy of the diagnosis.

CONCLUSION:

1H-MRS together with biopsy might improve the diagnostic accuracy in prostate cancer.

• Authors: Keisuke Saito, Tatsuro Kaminaga, Satoru Muto, Hisamitsu Ide, Koujiro Nishio, Yutaka Kamiyama, Hiroshi Okada, Yuichi Terado, Shigeru Furui, Shigeo Horie
• Journal: Anticancer research (Anticancer Res) 2008 May-Jun Vol. 28 Issue 3B Pg. 1899-904 ISSN: 0250-7005 [Print] Greece
• PMID: 18630478 (Publication Type: Journal Article)

Chemical References

• Protons
• Citric Acid
• Creatine
• Choline

Topics

• Aged
• Biopsy
• Choline (metabolism)
• Citric Acid (metabolism)
• Creatine (metabolism)
• Humans
• Magnetic Resonance Spectroscopy (methods)
• Male
• Middle Aged
• Neoplasm Staging
• Predictive Value of Tests
• Prostatectomy
• Prostatic Neoplasms (diagnosis, metabolism, pathology, surgery)
• Protons