Regression of uveal melanoma after plaque radiotherapy and thermotherapy based on chromosome 3 status.

Abstract

PURPOSE:

To evaluate regression rates after plaque radiotherapy and thermotherapy of uveal melanoma with chromosome 3 monosomy versus disomy.

DESIGN:

Noncomparative case series.

PARTICIPANTS:

Two hundred and seventy patients with uveal melanoma.

METHODS:

Fine needle aspiration biopsy was used at the time of plaque radiotherapy to sample tumor cells for genetic testing.

MAIN OUTCOME MEASURES:

Tumor thickness regression based on chromosome 3 status.

RESULTS:

At the time of plaque radiotherapy, the median tumor thickness was 4.0 mm for melanomas with chromosome 3 monosomy and 3.5 mm for those with disomy 3. The median tumor thickness (% original thickness) at 4, 8, 12, 15, and 18 months after radiotherapy for melanoma with monosomy 3 was 77%, 67%, 58%, 55%, and 50% and for those with disomy 3 was 82%, 70%, 69%, 67%, and 61%. The median monthly regression rate was 3.1% for tumors with monosomy 3 and 2.7% for those with disomy 3. The overall regression and monthly rate of regression was statistically greater at 12 months (P < 0.001) and 15 months (P = 0.003) for melanomas with monosomy 3 compared with disomy 3.

CONCLUSIONS:

Uveal melanomas with chromosome 3 monosomy showed faster and greater tumor thickness regression at 12 and 15 months after plaque radiotherapy and thermotherapy than melanomas with disomy 3.

• Authors: Carol L Shields, Carlos Bianciotto, Danielle Rudich, Miguel A Materin, Arupa Ganguly, Jerry A Shields
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 28 Issue 9 Pg. 1289-95 (Oct 2008) ISSN: 1539-2864 [Electronic] United States
• PMID: 18628721 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biopsy, Fine-Needle
• Brachytherapy
• Chromosome Aberrations
• Chromosomes, Human, Pair 3
• Humans
• Hyperthermia, Induced
• Melanoma (genetics, pathology, therapy)
• Middle Aged
• Monosomy
• Time Factors
• Treatment Outcome
• Uveal Neoplasms (genetics, pathology, therapy)
• Young Adult