Abstract |
14-3-3sigma an intracellular phosphoserine binding protein regulates different cellular signalling processes and is involved in cancer development. In this study, we examined the expression of 14-3-3sigma and evaluated its clinical significance in OSCC. Tumour tissue from 95 OSCC patients was analysed for 14-3-3sigma and p53 expression, respectively. The correlation of these proteins with survival and clinical parameters was assessed. 14-3-3sigma high expression was observed in 44.2% of OSCC patients. A significant role of 14-3-3sigma expression on survival was shown by Kaplan-Meier analysis. Median survival time was 4.1years for patients with 14-3-3sigma low tumours, compared with 1.36years for 14-3-3sigma high tumours (P=.0021). Subset analysis in patients receiving adjuvant chemotherapy showed that the overall survival was significantly decreased in 14-3-3sigma high tumours than in 14-3-3sigma low tumours (P=.02). p53 expression was not significant in univariate analyses. In multivariate regression analysis, 14-3-3sigma expression emerged as a significant independent parameter (P=.003). These results provide evidence that 14-3-3sigma expression is involved in OSCC and, in contrast to p53 expression represents a new prognostic marker for OSCC and therapy response. Pending validation targeting 14-3-3sigma might also be a new opportunity to improve therapy.
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Authors | Klaus Laimer, Nicola Blassnig, Gilbert Spizzo, Frank Kloss, Michael Rasse, Peter Obrist, Georg Schäfer, Alexander Perathoner, Raimund Margreiter, Albert Amberger |
Journal | Oral oncology
(Oral Oncol)
Vol. 45
Issue 2
Pg. 127-34
(Feb 2009)
ISSN: 1879-0593 [Electronic] England |
PMID | 18620895
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 14-3-3 Proteins
- Neoplasm Proteins
- Tumor Suppressor Protein p53
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Topics |
- 14-3-3 Proteins
(metabolism)
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(metabolism, mortality, therapy)
- Chemotherapy, Adjuvant
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mouth Neoplasms
(metabolism, mortality, therapy)
- Multivariate Analysis
- Neoplasm Proteins
(metabolism)
- Prognosis
- Survival Analysis
- Tumor Suppressor Protein p53
(metabolism)
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