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Prognostic significance of 14-3-3sigma expression in oral squamous cell carcinoma (OSCC).

Abstract
14-3-3sigma an intracellular phosphoserine binding protein regulates different cellular signalling processes and is involved in cancer development. In this study, we examined the expression of 14-3-3sigma and evaluated its clinical significance in OSCC. Tumour tissue from 95 OSCC patients was analysed for 14-3-3sigma and p53 expression, respectively. The correlation of these proteins with survival and clinical parameters was assessed. 14-3-3sigma high expression was observed in 44.2% of OSCC patients. A significant role of 14-3-3sigma expression on survival was shown by Kaplan-Meier analysis. Median survival time was 4.1years for patients with 14-3-3sigma low tumours, compared with 1.36years for 14-3-3sigma high tumours (P=.0021). Subset analysis in patients receiving adjuvant chemotherapy showed that the overall survival was significantly decreased in 14-3-3sigma high tumours than in 14-3-3sigma low tumours (P=.02). p53 expression was not significant in univariate analyses. In multivariate regression analysis, 14-3-3sigma expression emerged as a significant independent parameter (P=.003). These results provide evidence that 14-3-3sigma expression is involved in OSCC and, in contrast to p53 expression represents a new prognostic marker for OSCC and therapy response. Pending validation targeting 14-3-3sigma might also be a new opportunity to improve therapy.
AuthorsKlaus Laimer, Nicola Blassnig, Gilbert Spizzo, Frank Kloss, Michael Rasse, Peter Obrist, Georg Schäfer, Alexander Perathoner, Raimund Margreiter, Albert Amberger
JournalOral oncology (Oral Oncol) Vol. 45 Issue 2 Pg. 127-34 (Feb 2009) ISSN: 1879-0593 [Electronic] England
PMID18620895 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 14-3-3 Proteins
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53
Topics
  • 14-3-3 Proteins (metabolism)
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell (metabolism, mortality, therapy)
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mouth Neoplasms (metabolism, mortality, therapy)
  • Multivariate Analysis
  • Neoplasm Proteins (metabolism)
  • Prognosis
  • Survival Analysis
  • Tumor Suppressor Protein p53 (metabolism)

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