A surgical ankle sprain pain model in the rat: effects of morphine and indomethacin.

Abstract

Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.

• Authors: Hee Young Kim, Jigong Wang, Kyungsoon Chung, Jin Mo Chung
• Journal: Neuroscience letters (Neurosci Lett) Vol. 442 Issue 2 Pg. 161-4 (Sep 12 2008) ISSN: 0304-3940 [Print] Ireland
• PMID: 18620022 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Analgesics, Opioid
• Anti-Inflammatory Agents, Non-Steroidal
• Morphine
• Indomethacin

Topics

• Analgesics, Opioid (therapeutic use)
• Analysis of Variance
• Animals
• Ankle Injuries (complications, drug therapy)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Indomethacin (therapeutic use)
• Male
• Morphine (therapeutic use)
• Pain (drug therapy, etiology)
• Rats
• Rats, Sprague-Dawley
• Sprains and Strains (complications, drug therapy)
• Time Factors
• Weight-Bearing