Abstract | BACKGROUND: OBJECTIVE: To describe the clinical and microbiologic outcomes of patients who received tigecycline for the treatment of infections caused by Acinetobacter spp. at our institution. METHODS: A retrospective review was conducted of the medical records of 29 sequential patients who received tigecycline for treatment of Acinetobacter infections. The outcomes assessed for efficacy were clinical improvement or cure and microbiologic cure in evaluable patients. RESULTS: Patients received tigecycline a median of 30 days into hospitalization for a median of 11 days. Common indications were pneumonia (15 pts.), bacteremia (6), and urinary tract infection (3). Positive clinical outcomes (clinical cure or improvement) were seen in 8 (28%) of 29 patients. Of the 25 microbiologically evaluable patients, 11 (44%) had resolution of their cultures. Eleven patients had susceptibility testing performed, and the median minimum inhibitory concentration was 4 microg/mL (range 3-8). CONCLUSIONS:
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Authors | Jason C Gallagher, Heather M Rouse |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 42
Issue 9
Pg. 1188-94
(Sep 2008)
ISSN: 1542-6270 [Electronic] United States |
PMID | 18614749
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Tigecycline
- Minocycline
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Topics |
- Acinetobacter Infections
(drug therapy)
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(therapeutic use)
- Bacteremia
(drug therapy, microbiology)
- Bronchitis
(drug therapy, microbiology)
- Drug Resistance, Bacterial
- Humans
- Microbial Sensitivity Tests
- Middle Aged
- Minocycline
(analogs & derivatives, therapeutic use)
- Pneumonia, Bacterial
(drug therapy, microbiology)
- Retrospective Studies
- Tigecycline
- Urinary Tract Infections
(drug therapy, microbiology)
- Wound Infection
(drug therapy, microbiology)
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