Rubber-specific IgE in children with spina bifida.

Abstract

We attempted to determine the prevalence and clinical significance of rubber-specific IgE in a prospective case control study of 32 preoperative children with spina bifida, compared with 45 outpatient controls and 35 age-matched preoperative controls without spina bifida. A latex-specific radioallergosorbent test was positive in 11 of the 32 spina bifida patients (34%), compared with 1 (2%) and 4 (11%) of the respective controls (p less than 0.05). Within the spina bifida group 5 of 11 antibody-positive patients had a history of rubber-associated, intraoperative or otherwise idiopathic allergic episodes and 1 of 21 antibody-negative patients gave such a history (p = 0.012). Children with spina bifida have a significantly greater likelihood than controls of having IgE specific for rubber antigens. In addition, the presence of rubber-specific IgE is associated with a higher frequency of rubber-associated, intraoperative or idiopathic allergic reactions.

• Authors: J E Slater, L A Mostello, C Shaer
• Journal: The Journal of urology (J Urol) Vol. 146 Issue 2 ( Pt 2) Pg. 578-9 (Aug 1991) ISSN: 0022-5347 [Print] United States
• PMID: 1861303 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin E
• Rubber

Topics

• Adolescent
• Antigen-Antibody Reactions
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Humans
• Immunoglobulin E (analysis, immunology)
• Male
• Prospective Studies
• Radioallergosorbent Test
• Rubber
• Spinal Dysraphism (blood)