Spotlight on lanreotide Autogel in acromegaly.

Abstract

Lanreotide Autogel (ATG) [Somatuline Depot]The use of trade names is for product identification purposes only and does not imply endorsement. is a novel, long-acting preparation of the somatostatin analog lanreotide acetate that acts via somatostatin receptors to reduce both growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels. It is indicated for the management of acromegaly and, relative to most other licensed agents, it has a favorable pharmacokinetic profile that permits administration once every 28-42 days. Subcutaneous lanreotide ATG was an effective and generally well tolerated treatment in patients with acromegaly in well designed trials and extension studies of up to 4 years' duration. It was shown to be no less effective than intramuscular lanreotide long-acting (LA) microparticle treatment in these studies, with more limited data showing that lanreotide ATG therapy was as effective as intramuscular octreotide long-acting repeating (octreotide LAR) treatment. While both of these latter agents offer the advantage of treatment once every 28 days, lanreotide ATG also has the advantage of being available in a convenient pre-filled syringe and is given subcutaneously rather than intramuscularly like other somatostatin analogs. Thus it provides a valuable first-line option for the management of patients with acromegaly.

• Authors: Jamie D Croxtall, Lesley J Scott
• Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (BioDrugs) Vol. 22 Issue 4 Pg. 275-7 ( 2008) ISSN: 1173-8804 [Print] New Zealand
• PMID: 18611070 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Peptides, Cyclic
• lanreotide
• Somatostatin

Topics

• Acromegaly (drug therapy)
• Delayed-Action Preparations
• Humans
• Peptides, Cyclic (administration & dosage, adverse effects, therapeutic use)
• Somatostatin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)