Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: SUMMARY: Elevating HDL- apoA-I and apoA-II may be a more important therapeutic objective than increased HDL-cholesterol. Recent studies underscore the potential value of studying HDL functionality, particularly in the metabolic syndrome. Reverse cholesterol transport can only be reliably probed at present by studying the kinetics of HDL particles or apolipoproteins; new methods are needed for investigating cellular and whole body cholesterol turnover. In metabolic syndrome, HDL-raising therapies have differential impact on HDL kinetics, the optimal endpoint being to increase transport and concentration with unchanged or accelerated catabolism.
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Authors | Gerald F Watts, P Hugh R Barrett, Dick C Chan |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 19
Issue 4
Pg. 395-404
(Aug 2008)
ISSN: 0957-9672 [Print] England |
PMID | 18607187
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Adiponectin
- Cholesterol, HDL
- Homocysteine
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Topics |
- Adiponectin
(blood)
- Cholesterol, HDL
(blood, metabolism)
- Homocysteine
(blood)
- Humans
- Inflammation
(blood, metabolism)
- Kinetics
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