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Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice.

Abstract
The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.
AuthorsKouichirou Shin, Ayako Horigome, Koji Yamauchi, Mitsunori Takase, Tomoko Yaeshima, Keiji Iwatsuki
JournalBioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 72 Issue 7 Pg. 1932-5 (Jul 2008) ISSN: 1347-6947 [Electronic] England
PMID18603806 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Dextran Sulfate
  • Lactoperoxidase
Topics
  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents
  • Cattle
  • Colitis (chemically induced, drug therapy, pathology)
  • Dextran Sulfate
  • Lactoperoxidase (administration & dosage, pharmacology, therapeutic use)
  • Mice
  • Treatment Outcome

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