Abstract |
The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.
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Authors | Kouichirou Shin, Ayako Horigome, Koji Yamauchi, Mitsunori Takase, Tomoko Yaeshima, Keiji Iwatsuki |
Journal | Bioscience, biotechnology, and biochemistry
(Biosci Biotechnol Biochem)
Vol. 72
Issue 7
Pg. 1932-5
(Jul 2008)
ISSN: 1347-6947 [Electronic] England |
PMID | 18603806
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Dextran Sulfate
- Lactoperoxidase
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Topics |
- Administration, Oral
- Animals
- Anti-Inflammatory Agents
- Cattle
- Colitis
(chemically induced, drug therapy, pathology)
- Dextran Sulfate
- Lactoperoxidase
(administration & dosage, pharmacology, therapeutic use)
- Mice
- Treatment Outcome
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