Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy.

Abstract

The case of a 4-month-old male infant treated with combined surgery and chemotherapy for an aggressive recurrent melanotic neuroectodermal tumor of infancy (MNTI) on the top of the alveolar process of the mandible with a long-term follow-up is presented. Initial treatment comprised conservative local excision and curettage of the mandible. After several local recurrences and because radical surgical excision would give gross functional and aesthetic mutilation, finally complete, long-lasting remission was achieved with adjuvant chemotherapy, according to a neuroblastoma protocol (10-year follow-up). The reason for this protocol was because molecular genetic studies of this tumor showed loss of heterozygosity of chromosome 1p and gain of chromosome 7q analogue to neuroblastomas. A combination of surgery and chemotherapy should be the preferred treatment in case of a recurrence MNTI because optimal functional and aesthetic outcome.

• Authors: Johannus Neven, Christine Hulsbergen-van der Kaa, Jacqueline Groot-Loonen, Peter C M de Wilde, Matthais A W Merkx
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 106 Issue 4 Pg. 493-6 (Oct 2008) ISSN: 1528-395X [Electronic] United States
• PMID: 18602297 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vincristine
• Etoposide
• Carboplatin
• Ifosfamide

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carboplatin (administration & dosage)
• Chemotherapy, Adjuvant
• Chromosomes, Human, Pair 1
• Chromosomes, Human, Pair 7
• Comparative Genomic Hybridization
• Etoposide (administration & dosage)
• Humans
• Ifosfamide (administration & dosage)
• Infant
• Loss of Heterozygosity
• Male
• Mandibular Neoplasms (drug therapy, genetics, surgery)
• Neoplasm Recurrence, Local
• Neuroectodermal Tumor, Melanotic (drug therapy, genetics, surgery)
• Vincristine (administration & dosage)