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Development of human striatal anlagen after transplantation in a patient with Huntington's disease.

Abstract
Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
AuthorsPasquale Gallina, Marco Paganini, Letizia Lombardini, Riccardo Saccardi, Mirca Marini, Maria Teresa De Cristofaro, Pamela Pinzani, Francesca Salvianti, Clara Crescioli, Andrea Di Rita, Sandra Bucciantini, Claudia Mechi, Erica Sarchielli, Marco Moretti, Silvia Piacentini, Gaetano Gritti, Alberto Bosi, Sandro Sorbi, Giovanni Orlandini, Gabriella B Vannelli, Nicola Di Lorenzo
JournalExperimental neurology (Exp Neurol) Vol. 213 Issue 1 Pg. 241-4 (Sep 2008) ISSN: 1090-2430 [Electronic] United States
PMID18601923 (Publication Type: Clinical Trial, Journal Article)
Topics
  • Adult
  • Brain Tissue Transplantation (methods)
  • Cells, Cultured
  • Corpus Striatum (embryology, metabolism, transplantation)
  • Energy Metabolism (physiology)
  • Female
  • Fetal Tissue Transplantation (methods)
  • Functional Laterality (physiology)
  • Graft Survival (physiology)
  • Humans
  • Huntington Disease (pathology, physiopathology, therapy)
  • Magnetic Resonance Imaging
  • Neuronal Plasticity (physiology)
  • Neuronavigation
  • Positron-Emission Tomography
  • Stereotaxic Techniques
  • Treatment Outcome

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