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Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis.

Abstract
Capsaicin, a nonenamide derived from Capsicum plants, has proven useful in patients with vasomotor rhinitis. In the present study, we studied the effects of 15 micrograms capsaicin suspended in 100 microliters solution in patients with known vasomotor rhinitis. Drug was given 3 times/day for 3 days to each patient by means of a spray delivered to the nasal mucosa. Acute effects induced by the drug included painful sensation and secretion of nasal fluid but were no longer observed at the last capsaicin application. Patients recorded their symptoms over a 1-month period. The mean symptom score involving nasal obstruction and nasal secretion was markedly reduced by capsaicin treatment. We advance the hypothesis that the beneficial effect of drug treatment may be due to its specific action on the peripheral endings of primary sensory neurons leading to their functional blockade. Further randomized, double-blind, placebo-controlled trial is now needed.
AuthorsS Marabini, P G Ciabatti, G Polli, B M Fusco, P Geppetti
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 248 Issue 4 Pg. 191-4 ( 1991) ISSN: 0937-4477 [Print] Germany
PMID1859650 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Capsaicin
Topics
  • Administration, Intranasal
  • Adult
  • Capsaicin (administration & dosage, adverse effects)
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Middle Aged
  • Rhinitis, Vasomotor (drug therapy)

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