HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Reactivation of hepatitis B in a patient with Crohn's disease treated using infliximab.

Abstract
We encountered a case of reactivation of hepatitis B virus after administration of infliximab for Crohn's disease. The use of infliximab was considered because the patient displayed abdominal symptoms and perianal lesions. Transaminases were normal, and hepatitis B virus (HBV) DNA was undetectable before treatment, so no antiviral treatment was used, and infliximab and low-dose 6-mercaptopurine were administered. This treatment was effective, but liver dysfunction and reactivation of HBV were observed after the fourth injection of infliximab. This is the first report of Crohn's disease for which infliximab use was continued even after reactivation of HBV was observed. However, liver dysfunction was not improved by lamivudine. Antiviral treatment should be considered before administration of infliximab for patients with HBV.
AuthorsKeisuke Ojiro, Makoto Naganuma, Hirotoshi Ebinuma, Hiroyoshi Kunimoto, Shinichiro Tada, Haruhiko Ogata, Yasushi Iwao, Hidetsugu Saito, Toshifumi Hibi
JournalJournal of gastroenterology (J Gastroenterol) Vol. 43 Issue 5 Pg. 397-401 ( 2008) ISSN: 0944-1174 [Print] Japan
PMID18592158 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Antiviral Agents
  • DNA, Viral
  • Tumor Necrosis Factor-alpha
  • Infliximab
Topics
  • Adult
  • Anti-Inflammatory Agents (adverse effects, therapeutic use)
  • Antibodies, Monoclonal (adverse effects, therapeutic use)
  • Antiviral Agents (therapeutic use)
  • Colonoscopy
  • Crohn Disease (diagnosis, drug therapy)
  • DNA, Viral (analysis)
  • Female
  • Follow-Up Studies
  • Hepatitis B virus (drug effects, physiology)
  • Hepatitis B, Chronic (drug therapy, virology)
  • Humans
  • Infliximab
  • Recurrence
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)
  • Virus Activation (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: