Abstract | BACKGROUND:
Psoriasis is a chronic inflammatory skin disease associated with an HLA-Cw6 allele. Higher waist-hip ratio (WHR) and body mass index (BMI) may increase the risk of psoriasis vulgaris, but, to our knowledge, no evidence of the combined effects of HLA-Cw6 and BMI, WHR are available. OBJECTIVES: METHODS: The data of 466 patients and 177 controls were investigated and analyzed by a hospital-based case-control study and non-condition logistic regress model. RESULTS: There was a graded positive association of WHR and BMI with psoriasis vulgaris. Compared with a WHR of 0.80 or less than 0.80, the odds ratio (OR) was 2.36 (p < 0.01) for WHR 0.80-0.85, and 2.74 (p < 0.01) for WHR greater than 0.85. Compared with subjects with a BMI of 20 or less than 20, the multivariate OR of psoriasis were 1.20 (p > 0.05) for a BMI of 20-25, 1.84 (p < 0.05) for a BMI of more than 25 corresponding overweight (p for trend, <0.01). We found not only the risk of psoriasis for the individual with HLA-Cw6+ was 8.33 times greater than that for individual with HLA-Cw6(-) but also the risk increased approximately 35 times in individuals with HLA-Cw6+ and a overweight as compared with one with HLA-Cw6(-) and a non- overweight, and 17-fold when the individuals with HLA-Cw6+ and a WHR of more than 0.80 were compared with individuals with HLA-Cw6(-) and a WHR of 0.80 or less than 0.80, displaying the combined effect of HLA-Cw6, BMI and WHR (all p < 001). CONCLUSION: This study suggested that HLA-Cw6, overweight and higher waist-hip ratio are material risk factors of psoriasis vulgaris, specially the combined effects of HLA-Cw6 and BMI, WHR on psoriasis vulgaris in Chinese population.
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Authors | Yongtang Jin, Fengyu Zhang, Sen Yang, Yunming Kong, Fengli Xiao, Yong Hou, Xing Fan, Xuejun Zhang |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 52
Issue 2
Pg. 123-9
(Nov 2008)
ISSN: 0923-1811 [Print] Netherlands |
PMID | 18585007
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-C Antigens
- HLA-C*06 antigen
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Topics |
- Adolescent
- Adult
- Aged
- Alleles
- Asian People
(ethnology, genetics)
- Body Mass Index
- Case-Control Studies
- Child
- Child, Preschool
- China
- Female
- Genetic Predisposition to Disease
(ethnology, genetics)
- HLA-C Antigens
(genetics)
- Humans
- Infant
- Logistic Models
- Male
- Middle Aged
- Obesity
(complications, ethnology)
- Psoriasis
(epidemiology, ethnology, genetics)
- Risk Factors
- Waist-Hip Ratio
(statistics & numerical data)
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