[Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning].

Abstract

During consumption of drinking water containing manganese or combination of iron and manganese several biochemical patterns were altered in animal blood and liver tissue: content of SH-groups, total lipids, activity of alkaline phosphatase, content of cytochromes b5 and P-450 in liver microsomal fractions. Light and electron microscopy showed that local unspecific alterations of hepatocytes structure occurred in liver tissue. Activation of cytochromes in response to administration of the metals appears to involve alterations in phospholipid composition of endoplasmic reticulum.

• Authors: O A Modenova, A A Korolev, Z K Nikitina, A A Doktorov
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1991 Jan-Feb Vol. 37 Issue 1 Pg. 39-41 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izuchenie riada fermentnykh sistem i ul'trastruktury pecheni krys pri zhelezo-margantsevoĭ intoksikatsii.
• PMID: 1858339 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lipids
• Sulfhydryl Compounds
• Cytochromes b5
• Cytochrome P-450 Enzyme System
• Iron
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (blood, metabolism)
• Animals
• Cytochrome P-450 Enzyme System (biosynthesis, metabolism)
• Cytochromes b5 (biosynthesis, metabolism)
• Enzyme Activation
• Enzyme Induction
• Iron (toxicity)
• Lipids (blood)
• Male
• Manganese Poisoning
• Microscopy, Electron
• Microsomes, Liver (drug effects, enzymology, ultrastructure)
• Oxidation-Reduction
• Rats
• Sulfhydryl Compounds (blood)