Abstract | OBJECTIVES: The goal of this work is to evaluate the usefulness of NMP22 BladderChek in the diagnosis and follow-up of bladder cancer, comparing it with cystoscopy and urine cytology. METHODS: Group 1: 109 asymptomatic patients on follow up for bladder cancer underwent cystoscopy, cytology and NMP22 BladderChek. Group 2:15 patients with history of hematuria underwent cystoscopy and NMP22 BladderChek. RESULTS: Group 1: 9 patients had tumor relapse. Sensitivity was 25% for NMP22 test, 50% for citology and 100% for cystoscopy Specificity was 91.1%, 94.1% and 95% respectively. Group 2: 12 patients had bladder cancer. The sensitivity was of 83.3% for NMP22 BladderChek and 100% for cystoscopy. The specificity was of 100% for NMP22 BladderChek and 66.7% for cystoscopy. CONCLUSIONS: The low sensitivity of NMP22 Bladder-Chek invalidates it as alternative method to cystoscopy in the follow-up of bladder cancer. But it can be recommended for screening in patients without history of bladder cancer but with an increased risk (smokers, patients with dysuria and hematuria).
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Authors | Victoria Gonzalo Rodríguez, Lourdes Sanz Justo, Isabel de Miguel Santamaría, Javier Martínez de Iturrate, Ernesto Fernández del Busto |
Journal | Archivos espanoles de urologia
(Arch Esp Urol)
Vol. 61
Issue 3
Pg. 377-84
(Apr 2008)
ISSN: 0004-0614 [Print] Spain |
Vernacular Title | Empleo del NMP22 Bladder-Chek en el diagnóstico y seguimiento del cáncer de vejiga. |
PMID | 18581675
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Nuclear Proteins
- Reagent Strips
- nuclear matrix protein 22
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(urine)
- Carcinoma, Transitional Cell
(pathology)
- Cystoscopy
- Cytodiagnosis
- Female
- Hematuria
(etiology, urine)
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis, pathology)
- Neoplasm Staging
- Nuclear Proteins
(urine)
- Predictive Value of Tests
- Reagent Strips
- Urinary Bladder Neoplasms
(diagnosis, pathology)
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