HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[The use of NMP22 Bladder-Chek for the diagnosis and follow-up bladder cancer].

AbstractOBJECTIVES:
The goal of this work is to evaluate the usefulness of NMP22 BladderChek in the diagnosis and follow-up of bladder cancer, comparing it with cystoscopy and urine cytology.
METHODS:
Group 1: 109 asymptomatic patients on follow up for bladder cancer underwent cystoscopy, cytology and NMP22 BladderChek. Group 2:15 patients with history of hematuria underwent cystoscopy and NMP22 BladderChek.
RESULTS:
Group 1: 9 patients had tumor relapse. Sensitivity was 25% for NMP22 test, 50% for citology and 100% for cystoscopy Specificity was 91.1%, 94.1% and 95% respectively. Group 2: 12 patients had bladder cancer. The sensitivity was of 83.3% for NMP22 BladderChek and 100% for cystoscopy. The specificity was of 100% for NMP22 BladderChek and 66.7% for cystoscopy.
CONCLUSIONS:
The low sensitivity of NMP22 Bladder-Chek invalidates it as alternative method to cystoscopy in the follow-up of bladder cancer. But it can be recommended for screening in patients without history of bladder cancer but with an increased risk (smokers, patients with dysuria and hematuria).
AuthorsVictoria Gonzalo Rodríguez, Lourdes Sanz Justo, Isabel de Miguel Santamaría, Javier Martínez de Iturrate, Ernesto Fernández del Busto
JournalArchivos espanoles de urologia (Arch Esp Urol) Vol. 61 Issue 3 Pg. 377-84 (Apr 2008) ISSN: 0004-0614 [Print] Spain
Vernacular TitleEmpleo del NMP22 Bladder-Chek en el diagnóstico y seguimiento del cáncer de vejiga.
PMID18581675 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Nuclear Proteins
  • Reagent Strips
  • nuclear matrix protein 22
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (urine)
  • Carcinoma, Transitional Cell (pathology)
  • Cystoscopy
  • Cytodiagnosis
  • Female
  • Hematuria (etiology, urine)
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (diagnosis, pathology)
  • Neoplasm Staging
  • Nuclear Proteins (urine)
  • Predictive Value of Tests
  • Reagent Strips
  • Urinary Bladder Neoplasms (diagnosis, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: