HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Levodopa improves time-based prospective memory in Parkinson's disease.

Abstract
The present study was aimed at investigating the effect of acute levodopa administration on the performance of a group of individuals with Parkinson's disease (PD) on a time-based prospective memory task. Twenty PD patients and 15 healthy controls were administered a task that required executing three actions after 10 min had elapsed in three consecutive trials. Scores were computed for correct recall of the intention to perform the actions and for correct execution of the actions. PD participants were evaluated after a 12-hr drug wash-out in two conditions: (1) after levodopa administration ("on"); (2) without drug administration ("off"). In the "on" condition, PD patients were significantly more accurate in retrieving the intention to perform the actions than in the "off" condition and their performance was actually comparable to that of healthy controls. The increased accuracy in complying with the prospective memory task following levodopa medication supports the idea that dopamine depletion plays a role in the prospective memory deficits observed in PD patients.
AuthorsAlberto Costa, Antonella Peppe, Livia Brusa, Carlo Caltagirone, Ilaria Gatto, Giovanni Augusto Carlesimo
JournalJournal of the International Neuropsychological Society : JINS (J Int Neuropsychol Soc) Vol. 14 Issue 4 Pg. 601-10 (Jul 2008) ISSN: 1469-7661 [Electronic] England
PMID18577289 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiparkinson Agents
  • Dopamine Agonists
  • Levodopa
Topics
  • Aged
  • Antiparkinson Agents (therapeutic use)
  • Attention (drug effects)
  • Dopamine Agonists (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Intention
  • Levodopa (therapeutic use)
  • Male
  • Mental Recall (drug effects)
  • Middle Aged
  • Parkinson Disease (drug therapy)
  • Time Perception (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: