Disposition of lypophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles in rats and their effect on zoxazolamine paralysis time.

Abstract

The fate of lyophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles was studied in male Wistar rats after p.o. administration. It was found that at least 4% of the dose of 14C was absorbed from the gastrointestinal tract after a single dose with these nanoparticles. Some radioactivity (less than 0.15% of dose) was found 7 d after administration in lung, spleen and liver. As expected excretion of the label was predominated via the feces. Ten d of p.o. treatment of rats with lyophilized nanoparticles (1 g/kg of body weight) was shown to prolong significantly zoxazolamine paralysis time. This result suggests that lyophilized nanoparticles decreased elimination of zoxazolamine.

• Authors: M Kukan, V Koprda, S Bezek, J Kálal, J Labský, T Trnovec
• Journal: Die Pharmazie (Pharmazie) Vol. 46 Issue 1 Pg. 37-9 (Jan 1991) ISSN: 0031-7144 [Print] Germany
• PMID: 1857727 (Publication Type: Journal Article)

Chemical References

• Acrylates
• Delayed-Action Preparations
• Methacrylates
• Methylmethacrylates
• Methylmethacrylate
• hydroxyethyl methacrylate
• n-butyl acrylate
• Zoxazolamine

Topics

• Acrylates (pharmacokinetics, pharmacology)
• Administration, Oral
• Animals
• Delayed-Action Preparations
• Feces (chemistry)
• Freeze Drying
• Intestinal Absorption
• Male
• Methacrylates (pharmacokinetics, pharmacology)
• Methylmethacrylate
• Methylmethacrylates (pharmacokinetics, pharmacology)
• Microspheres
• Paralysis (chemically induced, physiopathology)
• Rats
• Rats, Inbred Strains
• Time Factors
• Tissue Distribution
• Zoxazolamine