Disposition of lypophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles in rats and their effect on zoxazolamine paralysis time.

The fate of lyophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles was studied in male Wistar rats after p.o. administration. It was found that at least 4% of the dose of 14C was absorbed from the gastrointestinal tract after a single dose with these nanoparticles. Some radioactivity (less than 0.15% of dose) was found 7 d after administration in lung, spleen and liver. As expected excretion of the label was predominated via the feces. Ten d of p.o. treatment of rats with lyophilized nanoparticles (1 g/kg of body weight) was shown to prolong significantly zoxazolamine paralysis time. This result suggests that lyophilized nanoparticles decreased elimination of zoxazolamine.
AuthorsM Kukan, V Koprda, S Bezek, J Kálal, J Labský, T Trnovec
JournalDie Pharmazie (Pharmazie) Vol. 46 Issue 1 Pg. 37-9 (Jan 1991) ISSN: 0031-7144 [Print] GERMANY
PMID1857727 (Publication Type: Journal Article)
Chemical References
  • Acrylates
  • Delayed-Action Preparations
  • Methacrylates
  • Methylmethacrylates
  • Methylmethacrylate
  • hydroxyethyl methacrylate
  • n-butyl acrylate
  • Zoxazolamine
  • Acrylates (pharmacokinetics, pharmacology)
  • Administration, Oral
  • Animals
  • Delayed-Action Preparations
  • Feces (chemistry)
  • Freeze Drying
  • Intestinal Absorption
  • Male
  • Methacrylates (pharmacokinetics, pharmacology)
  • Methylmethacrylate
  • Methylmethacrylates (pharmacokinetics, pharmacology)
  • Microspheres
  • Paralysis (chemically induced, physiopathology)
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Tissue Distribution
  • Zoxazolamine

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