Abstract | BACKGROUND: METHODS: RESULTS: Patients in both groups had similar preoperative characteristics. Patients in the high-dose insulin group had higher blood insulin concentrations and tighter blood glucose control. There were lower levels of IL6 (150 pg/dL vs 245 pg/dL, p = 0.03), IL-8 (49 pg/dL vs 74 pg/dL, p = 0.05), and TNFalpha (2.2 pg/dL vs 3.0 pg/dL, p = 0.04) in group II in the early postoperative period. CONCLUSIONS: High-dose insulin therapy blunts the early postoperative surge in inflammatory response to CPB as reflected by decreased levels of IL6, IL8, and TNFalpha.
|
Authors | Turki Albacker, George Carvalho, Thomas Schricker, Kevin Lachapelle |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 86
Issue 1
Pg. 20-7
(Jul 2008)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 18573392
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Blood Glucose
- Inflammation Mediators
- Insulin
- Troponin
|
Topics |
- Aged
- Blood Glucose
(analysis)
- Cardiopulmonary Bypass
(adverse effects, methods)
- Coronary Artery Bypass
(adverse effects, methods)
- Coronary Artery Disease
(complications, surgery)
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Humans
- Inflammation Mediators
(blood)
- Infusions, Intravenous
- Insulin
(administration & dosage)
- Intraoperative Care
(methods)
- Male
- Postoperative Complications
(physiopathology, prevention & control)
- Probability
- Reference Values
- Risk Assessment
- Survival Analysis
- Systemic Inflammatory Response Syndrome
(epidemiology, etiology, prevention & control)
- Treatment Outcome
- Troponin
(blood)
- Vascular Resistance
(drug effects, physiology)
|