Age-related toxic effects and recovery from okadaic acid treatment in Enchytraeus crypticus (Annelida: Oligochaeta).

Abstract

The effects of 48 h okadaic acid (OA) treatment and the ability to recover the induced toxicological injuries were examined in Enchytraeus crypticus of different ages (25 days and 3 months). The results demonstrated that the older worms are more sensitive to the toxin and show less capacity to recover. After 48 h OA treatment, the structural organization of the chloragogenous tissue appeared modified and associated with an immune response involving a higher number of circulating coelomocytes immunoreactive to anti-IL-6 antibody. The toxin effects were more evident in 3-month-old animals compared to specimens aged 25 days. Regarding the morpho-functional recovery from the induced modifications, first signs of recuperation were observed in younger worms at 48 h, and recovery was almost complete within 1 week. In older animals, the morphology of the chloragogenous tissue had not been restored, while a reduction in coelomocyte number was found after 1 week.

• Authors: A Franchini, E Ottaviani
• Journal: Toxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 52 Issue 1 Pg. 115-21 (Jul 2008) ISSN: 0041-0101 [Print] England
• PMID: 18573271 (Publication Type: Journal Article)

Chemical References

• Okadaic Acid

Topics

• Age Factors
• Animals
• Okadaic Acid (toxicity)
• Oligochaeta (drug effects, immunology, physiology)