Abstract | BACKGROUND & AIMS: METHODS: RESULTS: The Gen+Ipr group had the lowest number of palpable tumors and adenocarcinomas per group, the least palpable tumors per rat, and the highest serum total and non- HDL cholesterol levels. No changes in circulating levels of indicators of oxidative stress were detected due to treatment. CONCLUSIONS: The findings of this study imply that the combination of genistin and ipriflavone is effective in suppressing mammary methylnitrosurea-induced tumorigenesis and also the lipid environment of the tumor cells that impact tumor growth or proliferation. Further studies are needed to establish the optimal dose of genistin and ipriflavone, individually or in combination, for the prevention of mammary tumorigenesis.
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Authors | Shirin Hooshmand, Dania A Khalil, Genoveva Murillo, Keith Singletary, Savitri K Kamath, Bahram H Arjmandi |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 27
Issue 4
Pg. 643-8
(Aug 2008)
ISSN: 1532-1983 [Electronic] England |
PMID | 18571816
(Publication Type: Journal Article)
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Chemical References |
- Anticarcinogenic Agents
- Isoflavones
- genistin
- Methylnitrosourea
- ipriflavone
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Topics |
- Animals
- Anticarcinogenic Agents
(pharmacology)
- Antineoplastic Combined Chemotherapy Protocols
- Female
- Isoflavones
(pharmacology)
- Lipid Metabolism
(drug effects, physiology)
- Mammary Neoplasms, Experimental
(chemically induced, prevention & control)
- Methylnitrosourea
(toxicity)
- Rats
- Rats, Sprague-Dawley
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