NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain.

Abstract

Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the clearance of central nervous system viral infections has not been explored. Using the Theiler's murine encephalomyelitis virus model, the authors found that NKG2D-positive CD8+ cytotoxic T cells enter the brain, that NKG2D ligands are expressed in the brain during acute infection, and that interruption of NKG2D ligand recognition via treatment with a function-blocking antibody attenuates the efficacy of viral clearance from the central nervous system.

• Authors: Chandra Deb, Charles L Howe
• Journal: Journal of neurovirology (J Neurovirol) Vol. 14 Issue 3 Pg. 261-6 (May 2008) ISSN: 1538-2443 [Electronic] United States
• PMID: 18569460 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histocompatibility Antigens Class I
• Klrk1 protein, mouse
• Ligands
• NK Cell Lectin-Like Receptor Subfamily K
• Receptors, Immunologic
• Receptors, Natural Killer Cell

Topics

• Acute Disease
• Animals
• Brain (immunology, virology)
• Cardiovirus Infections (immunology, virology)
• Cell Movement
• Histocompatibility Antigens Class I (metabolism)
• Ligands
• Mice
• Mice, Inbred C57BL
• NK Cell Lectin-Like Receptor Subfamily K
• Receptors, Immunologic (physiology)
• Receptors, Natural Killer Cell
• T-Cell Antigen Receptor Specificity
• T-Lymphocytes, Cytotoxic (immunology, metabolism)
• Theilovirus (pathogenicity, physiology)
• Virulence