Acute generalized exanthematous pustulosis (AGEP, toxic pustuloderma, pustular
drug eruption) is a not uncommon cutaneous reaction pattern that is usually related to
drug administration. The eruption is of sudden onset and appears 7-10 days after the medication is started. A 22-year-old male patient who was a student at a chemical faculty attended our outpatient clinic with a complaint of pustular eruption on his face. According to his history, the eruption started with
pruritus and
erythema on his chin 3 days ago and spread to his face and chest. He explained that he had performed an experiment with
sulfuric acid and
bromic acid and was exposed to their vapor. His dermatological examination revealed
erythema and pustules on his cheeks, on his chin, above his upper lip, and on his eyebrows. He also had a few pustules on his chest. There were no ocular, mucous membrane, or pulmonary symptoms. Histopathological examination of the skin biopsy specimen revealed superficial orthokeratosis, focal subcorneal pustule formation, and perivascular chronic inflammatory cell infiltration in superficial dermis. After administration of systemic
antihistamines and wet dressing topically, we observed rapid healing of the lesions. Because there was no systemic
drug intake in his history, we were concerned that exposure to
sulfuric acid and
bromic acid vapor caused AGEP in this patient. We present this rare case to show that the vapor of chemical materials may cause AGEP or other
drug eruptions.