Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis.

Abstract

CONCLUSIONS:

Intranasal microemulsion treatment can attenuate allergen challenge-induced nasal symptoms and plasma exudation in allergic rhinitis. We hypothesize that the mechanism of action involves modification of the allergen-mucosa interaction. The present observation suggests a novel principle for prevention in allergic rhinitis.

OBJECTIVE:

To evaluate a specific microemulsion as a treatment for allergic rhinitis in an acute allergen challenge model.

PATIENTS AND METHODS:

Patients with allergic rhinitis were examined out of the pollen season. Treatment with a single dose of a specific microemulsion was given in a single-blind, placebo-controlled, and crossover design using a nasal pool device. Nasal allergen challenges were carried out and symptoms of allergic rhinitis were scored. Furthermore, nasal lavages were performed and levels of the plasma protein alpha 2-macroglobulin were measured as an index of exudative inflammation.

RESULTS:

The allergen challenges produced significant increases in nasal symptoms (p=0.007) and in nasal lavage fluid levels of alpha 2-macroglobulin (p=0.008). The challenge-induced symptoms as well as the plasma exudation were attenuated by treatment with the microemulsion (p=0.016 and 0.012, respectively, compared with placebo).

• Authors: Morgan Andersson, Lennart Greiff, Per Wollmer
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 128 Issue 6 Pg. 666-9 (Jun 2008) ISSN: 0001-6489 [Print] England
• PMID: 18568502 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Allergens
• Emulsions
• alpha-Macroglobulins

Topics

• Administration, Intranasal
• Adult
• Allergens (administration & dosage, immunology)
• Desensitization, Immunologic
• Emulsions
• Female
• Humans
• Male
• Nasal Lavage Fluid (chemistry)
• Pollen (immunology)
• Rhinitis, Allergic, Seasonal (immunology, therapy)
• Single-Blind Method
• alpha-Macroglobulins (analysis)