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Biological response genes after single dose administration of interferon beta-1b to healthy male volunteers.

Abstract
Treatment with interferon beta-1b (IFNB-1b) is clinically effective in multiple sclerosis patients. However, the mechanism of action is only partially understood, and validated biological response markers are lacking. We assessed IFNB-1b-induced transcriptional changes by microarray technology. Healthy male volunteers received 250 mug IFNB-1b or placebo in a double-blind, randomized controlled trial (n=5 per group). Most transcripts demonstrated peak levels after 6-12 h and returned to baseline after 48 h. We identified 227 differentially regulated genes including novel and previously described markers. This panel may become a valuable tool for development of new IFNB-1b formulations and assessment of clinical drug effects.
AuthorsJan Hilpert, Johanna M Beekman, Susanne Schwenke, Kristin Kowal, David Bauer, Johannes Lampe, Rupert Sandbrink, Jürgen F Heubach, Steffen Stürzebecher, Joachim Reischl
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 199 Issue 1-2 Pg. 115-25 (Aug 13 2008) ISSN: 0165-5728 [Print] Netherlands
PMID18565596 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Adjuvants, Immunologic
  • Immunologic Factors
  • Interferon beta-1b
  • Interferon-beta
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Adult
  • Double-Blind Method
  • Gene Expression (drug effects)
  • Gene Expression Profiling
  • Humans
  • Immunologic Factors (genetics)
  • Interferon beta-1b
  • Interferon-beta (pharmacology)
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Principal Component Analysis
  • Reverse Transcriptase Polymerase Chain Reaction

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