[The effect of thymalin on the count of large granular lymphocytes in the peripheral blood of mice with leukemia P388].

Abstract

Effect of thymaline injections on peripheral blood natural killer cells in mice with p388 leukemia has been studied. The content of natural killers that have been identified as large granular lymphocytes decreased in blood of leukemia mice. Multiple thymaline injections (0.66 mg/kg) maintain the numbers of the lymphocytes at the level of control animals but did not increase the life span of leukemia mice.

• Authors: Iu N Potapov, D V Khaleev, T V Krutova, V S Pashkova
• Journal: Izvestiia Akademii nauk SSSR. Seriia biologicheskaia (Izv Akad Nauk SSSR Biol) 1991 Jan-Feb Issue 1 Pg. 133-5 ISSN: 0002-3329 [Print] Russia (Federation)
• Vernacular Title: Vliianie timalina na soderzhanie bol'shikh granuliarnykh limfotsitov v perifericheskoĭ krovi mysheĭ s leĭkozom P388.
• PMID: 1856357 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Thymus Hormones
• thymalin

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Drug Screening Assays, Antitumor
• Killer Cells, Natural (drug effects)
• Leukemia P388 (blood, drug therapy, mortality)
• Leukocyte Count (drug effects)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Thymus Hormones (therapeutic use)