Efficacy and safety of deep sclerectomy in uveitic glaucoma.

Abstract

PURPOSE:

To evaluate the safety and efficacy of deep sclerectomy with implant and mitomycin C in uveitic glaucoma. Design Prospective, noncomparative case study.

PATIENTS AND METHODS:

Nine patients (13 eyes) with uncontrolled uveitic glaucoma underwent deep sclerectomy with implant from 2002 to 2006. All patients had their uveitis controlled before and after surgery with anti-inflammatory therapy. Main outcome measures Control of intraocular pressure. A secondary outcome measure was the number of antiglaucoma medications required to achieve the desired intraocular pressure. Visual acuity and complication associated with the surgery were monitored.

RESULTS:

Mean follow-up was 21 months (range 12-54 months). Intraocular pressure (IOP) was reduced from a mean preoperative value of 28.7 mmHg to a mean postoperative value of 13.85 mmHg (Wilcoxon signed rank test P = 0.005). At the most recent visit, complete success was obtained in 84.6%, qualified success was obtained in 7.7%, and complete failure in 7.7%. Mean number of antiglaucoma medications was reduced from 3.07 to 0.2 (Wilcoxon signed rank test P = 0.001). Neodymium:YAG goniopuncture was performed in two eyes. Postoperative complications included transient hypotony with maculopathy in one eye, shallow choroidal effusions in two eyes, and progression of cataract in four eyes.

CONCLUSION:

Deep sclerectomy with implant in uveitic glaucoma appeared to be effective in controlling the IOP at short-term follow-up with no serious postoperative side-effects.

• Authors: Saleh A Al Obeidan, Essam A Osman, Abdulrahman M Al-Muammar, Ahmed M Abu El-Asrar
• Journal: International ophthalmology (Int Ophthalmol) Vol. 29 Issue 5 Pg. 367-72 (Oct 2009) ISSN: 1573-2630 [Electronic] Netherlands
• PMID: 18563298 (Publication Type: Journal Article)

Chemical References

• Mitomycin

Topics

• Adolescent
• Adult
• Child
• Drug Delivery Systems (instrumentation)
• Female
• Glaucoma (drug therapy, etiology, physiopathology, surgery)
• Glaucoma Drainage Implants
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Postoperative Care
• Postoperative Complications
• Postoperative Period
• Prospective Studies
• Sclerostomy (adverse effects, methods)
• Surgical Sponges
• Treatment Outcome
• Uveitis (complications)
• Young Adult