Solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in the treatment of moderate acne.

Abstract

BACKGROUND:

Benzoyl peroxide (BPO) is poorly soluble. A solubilized formulation of BPO has been developed to maximize its bioavailability and enhance follicular penetration.

METHODS:

Patients with acne vulgaris were randomly assigned to receive solubilized BPO 5% gel on one side of the face and a BPO 5%/clindamycin 1% combination product on the contralateral side, twice daily for 4 weeks.

RESULTS:

Of 23 patients enrolled, 100% completed the study. Reductions in lesion count with the solubilized BPO gel were at least as great as with BPO/clindamycin--and significantly greater (P< or =.05) for noninflammatory lesions at week 1 and inflammatory lesions at week 4. Both regimens were generally well tolerated and patient satisfaction was comparable.

CONCLUSIONS:

Solubilized BPO 5% gel monotherapy offers significantly greater efficacy, and comparable patient satisfaction, compared with BPO/clindamycin. The early reduction in lesion counts observed with the solubilized BPO gel in the absence of an antibiotic is clinically relevant.

• Authors: Emil Tanghetti, Leon Kircik, David Wilson, Sunil Dhawan
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 7 Issue 6 Pg. 534-8 (Jun 2008) ISSN: 1545-9616 [Print] United States
• PMID: 18561583 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Dermatologic Agents
• Drug Combinations
• Gels
• Clindamycin
• Benzoyl Peroxide

Topics

• Acne Vulgaris (drug therapy)
• Administration, Cutaneous
• Adolescent
• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Benzoyl Peroxide (administration & dosage, adverse effects, therapeutic use)
• Child
• Clindamycin (administration & dosage, adverse effects, therapeutic use)
• Dermatologic Agents (administration & dosage, adverse effects, therapeutic use)
• Drug Administration Schedule
• Drug Combinations
• Female
• Gels
• Humans
• Male
• Middle Aged
• Patient Satisfaction
• Treatment Outcome