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Acute oxalate nephropathy causing late renal transplant dysfunction due to enteric hyperoxaluria.

Abstract
Calcium oxalate (CaOx) deposition in the renal allograft is an under recognized and important cause of acute tubular injury and early allograft dysfunction. We present a case of late transplant dysfunction due to acute oxalate nephropathy. The patient presented with diarrhea and deteriorating graft function, and a diagnosis of enteric hyperoxaluria secondary to pancreatic insufficiency was made. This had occurred, as the patient had been noncompliant with his pancreatic enzyme replacement therapy. Treatment to reduce his circulating oxalate load was initiated, including twice-daily hemodialysis, low fat and oxalate diet and appropriate administration of pancreatic enzyme supplements. Graft function subsequently recovered. The possibility of fat malabsorption leading to enteric hyperoxaluria should be considered in renal graft recipients presenting with loose stools and graft dysfunction.
AuthorsA C Rankin, S B Walsh, S A Summers, M P Owen, M A Mansell
JournalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 8 Issue 8 Pg. 1755-8 (Aug 2008) ISSN: 1600-6143 [Electronic] United States
PMID18557738 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Calcium Oxalate
Topics
  • Acute Disease
  • Acute Kidney Injury (etiology)
  • Aged
  • Calcium Oxalate (adverse effects)
  • Exocrine Pancreatic Insufficiency (complications)
  • Humans
  • Hyperoxaluria (complications, etiology)
  • Kidney Transplantation
  • Male
  • Renal Dialysis
  • Treatment Outcome

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