Abstract | INTRODUCTION: OBJECTIVES: This article reports 3 cases of HCQ-induced AGEP and reviews similar cases in the published literature. CASE SUMMARIES: The first case involved a 36-year-old woman with a 10-year history of rheumatoid arthritis and Sjögren's syndrome who had begun a 25-day course of HCQ 100 mg BID due to lack of response to a corticosteroid, with a skin reaction developing 21 days into the new treatment. In the second case, a 70-year-old man with poorly controlled rheumatoid arthritis had begun a course of oral HCQ 100 mg BID 20 days before development of AGEP. The final case involved a 79-year-old woman with polymyalgia rheumatica who had been receiving HCQ 100 mg BID as a steroid-sparing agent for 22 days, with rash developing 20 days after the initiation of HCQ. Sixteen cases of HCQ-induced AGEP were identified in the literature, including some that may have been reported under a different name but were consistent with a clinical diagnosis of AGEP. The US Food and Drug Administration has mandated a change to the labeling for HCQ to include AGEP among potential adverse dermatologic reactions to the drug. CONCLUSIONS: This article reports 3 cases of AGEP related to administration of HCQ. HCQ-induced AGEP is a rare but severe, extensive, and acute reaction. No specific therapy is available, and correct diagnosis generally leads to spontaneous resolution once the causative drug has been withdrawn.
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Authors | Andrea Paradisi, Leonardo Bugatti, Teresa Sisto, Giorgio Filosa, Pier Luigi Amerio, Rodolfo Capizzi |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 30
Issue 5
Pg. 930-40
(May 2008)
ISSN: 0149-2918 [Print] United States |
PMID | 18555940
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Hydroxychloroquine
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Topics |
- Acute Disease
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- Exanthema
(chemically induced)
- Female
- Humans
- Hydroxychloroquine
(adverse effects)
- Male
- Skin Diseases, Vesiculobullous
(chemically induced)
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