Abstract | BACKGROUND: HYPOTHESIS: STUDY DESIGN: Controlled laboratory study. METHODS: Forty mice underwent bilateral partial gastrocnemius lacerations. Mice were assigned randomly to a control group (tap water), a low-dose angiotensin receptor blocker group ( losartan, 0.05 mg/mL), or a high-dose angiotensin receptor blocker group (0.5 mg/mL). The medication was dissolved in tap water and administered enterally. Mice were sacrificed 3 or 5 weeks after injury, and the lacerated muscles were examined histologically for muscle regeneration and fibrosis. RESULTS: Compared with control mice at 3 and 5 weeks, angiotensin receptor blocker-treated mice exhibited a histologic dose-dependent improvement in muscle regeneration and a measurable reduction in fibrous tissue formation within the area of injury. CONCLUSION: CLINICAL RELEVANCE:
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Authors | Hany S Bedair, Tharun Karthikeyan, Andres Quintero, Yong Li, Johnny Huard |
Journal | The American journal of sports medicine
(Am J Sports Med)
Vol. 36
Issue 8
Pg. 1548-54
(Aug 2008)
ISSN: 1552-3365 [Electronic] United States |
PMID | 18550776
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Losartan
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Topics |
- Angiotensin II Type 1 Receptor Blockers
(administration & dosage)
- Animals
- Dose-Response Relationship, Drug
- Fibrosis
(drug therapy)
- Losartan
(administration & dosage)
- Mice
- Models, Animal
- Muscle, Skeletal
(injuries, metabolism)
- Random Allocation
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