Desonide: a review of formulations, efficacy and safety.

Abstract

BACKGROUND:

Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses. The favorable safety profile of this topical agent makes it ideal for patients of all ages.

OBJECTIVE:

This article provides a review of desonide's history, pharmacodynamic properties, vehicle technology, efficacy and safety.

METHODS:

Randomized controlled trials, as well as open-label and non-comparative studies, case series and reports, experimental models, and data from the Galderma pharmacovigiliance program were reviewed in order to address the clinical efficacy and safety of desonide.

RESULTS/CONCLUSION:

Clinical efficacy and safety have been proven in multiple clinical trials. In addition to cream, lotion and ointment formulations, the recently developed hydrogel and foam preparations have increased desonide's versatility and patient tolerability.

• Authors: Nr Kahanek, Cg Gelbard, Aa Hebert
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 17 Issue 7 Pg. 1097-104 (Jul 2008) ISSN: 1744-7658 [Electronic] England
• PMID: 18549345 (Publication Type: Journal Article, Review)

Chemical References

• Dosage Forms
• Desonide

Topics

• Chemistry, Pharmaceutical
• Desonide (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Dosage Forms
• Humans