Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats.

Abstract

The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch-Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxanthine-injected group. Treated-group received intrastriatal hypoxanthine solution 30 min before training session (memory acquisition) or immediately after training session (memory consolidation) or 30 before test session (memory retrieval) on step-down inhibitory avoidance task. Results show that hypoxanthine administration caused significant memory impairment in all periods tested. These results show that intrastriatal hypoxanthine administration provoked memory process impairment of step-down inhibitory avoidance task, an effect that might be related to the cognitive memory alterations in Lesch-Nyhan patients.

• Authors: Caren Serra Bavaresco, Juliana Ben, Fabria Chiarani, Carlos Alexandre Netto, Angela Terezinha Souza Wyse
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 90 Issue 4 Pg. 594-7 (Oct 2008) ISSN: 0091-3057 [Print] United States
• PMID: 18547623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoxanthine

Topics

• Animals
• Avoidance Learning (drug effects)
• Basal Ganglia (physiology)
• Hypoxanthine (administration & dosage, pharmacology)
• Male
• Memory (drug effects)
• Microinjections
• Neostriatum
• Rats
• Rats, Wistar
• Stereotaxic Techniques