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Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis.

Abstract
Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro. The concentration dependency of the inhibitory effect was tested using the MTT assay. The presence of reactive oxygen species, such as singlet oxygen and superoxide, was detected using electron paramagnetic resonance spectroscopy with selected spin traps and confocal microscopy in cultures exposed to these carbaporphyrin ketals. These unique porphyrinoids show promise as potent inhibitors of Leishmania.
AuthorsJustin B Morgenthaler, Steven J Peters, David L Cedeño, Manuel H Constantino, Kevin A Edwards, Erin M Kamowski, Jennifer C Passini, Brian E Butkus, Alexandra M Young, Timothy D Lash, Marjorie A Jones
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 16 Issue 14 Pg. 7033-8 (Jul 15 2008) ISSN: 1464-3391 [Electronic] England
PMID18541431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Porphyrins
  • Reactive Oxygen Species
  • Trypanocidal Agents
Topics
  • Animals
  • Electron Spin Resonance Spectroscopy
  • Leishmania (drug effects)
  • Leishmaniasis (therapy)
  • Microscopy, Confocal
  • Photochemotherapy (methods)
  • Porphyrins (pharmacology, therapeutic use)
  • Reactive Oxygen Species (analysis)
  • Trypanocidal Agents

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