Abstract |
We have used an immunoradiometric assay (IRMA) to measure intact PTH. The serum-levels of PTH followed a log-normal distribution in a population of 85 healthy post-menopausal women, with a geometric mean of 1.9 pmol/l and a range of 0.8-6.1 pmol/l. The correlation between measurements performed using the IRMA and a radioimmunoassay which measured the C-terminal portion of the PTH molecule was 0.85. It was only the IRMA, however, that could measure subnormal values. Two of 27 patients with primary hyperparathyroidism had PTH-values in the upper reference interval. The rest of the patients had elevated levels. Patients with hypercalcemia due to malignancy had subnormal or low normal (less than 2.5 pmol/l) PTH values. Half of the patients with hypoparathyroidism had PTH below the limit of detection. Four subjects with familial hypercalciuric hypercalcemia had normal (3) or slightly elevated PTH-levels.
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Authors | K I Birkeland, J A Falch, K M Gautvik, F T Gjestvang, N Holst, E Haug |
Journal | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
(Tidsskr Nor Laegeforen)
Vol. 111
Issue 15
Pg. 1840-4
(Jun 10 1991)
ISSN: 0029-2001 [Print] Norway |
Vernacular Title | Måling av intakt parathormon hos pasienter med kalsiumforstyrrelser. |
PMID | 1853314
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Parathyroid Hormone
- Calcium
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Topics |
- Adult
- Calcium
(metabolism)
- Humans
- Hypercalcemia
(blood, etiology)
- Hypoparathyroidism
(blood)
- Immunoradiometric Assay
(methods)
- Middle Aged
- Parathyroid Hormone
(blood)
- Reference Values
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