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[Determination of intact parathyroid hormone in patients with calcium metabolism disorders].

Abstract
We have used an immunoradiometric assay (IRMA) to measure intact PTH. The serum-levels of PTH followed a log-normal distribution in a population of 85 healthy post-menopausal women, with a geometric mean of 1.9 pmol/l and a range of 0.8-6.1 pmol/l. The correlation between measurements performed using the IRMA and a radioimmunoassay which measured the C-terminal portion of the PTH molecule was 0.85. It was only the IRMA, however, that could measure subnormal values. Two of 27 patients with primary hyperparathyroidism had PTH-values in the upper reference interval. The rest of the patients had elevated levels. Patients with hypercalcemia due to malignancy had subnormal or low normal (less than 2.5 pmol/l) PTH values. Half of the patients with hypoparathyroidism had PTH below the limit of detection. Four subjects with familial hypercalciuric hypercalcemia had normal (3) or slightly elevated PTH-levels.
AuthorsK I Birkeland, J A Falch, K M Gautvik, F T Gjestvang, N Holst, E Haug
JournalTidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke (Tidsskr Nor Laegeforen) Vol. 111 Issue 15 Pg. 1840-4 (Jun 10 1991) ISSN: 0029-2001 [Print] Norway
Vernacular TitleMåling av intakt parathormon hos pasienter med kalsiumforstyrrelser.
PMID1853314 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Parathyroid Hormone
  • Calcium
Topics
  • Adult
  • Calcium (metabolism)
  • Humans
  • Hypercalcemia (blood, etiology)
  • Hypoparathyroidism (blood)
  • Immunoradiometric Assay (methods)
  • Middle Aged
  • Parathyroid Hormone (blood)
  • Reference Values

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