Abstract | BACKGROUND: Asymmetrical dimethylarginine (ADMA) was found to be increased in conditions associated with atherosclerosis and metabolic disorders. We investigated ADMA in obese juveniles with pre-atherosclerotic symptoms and in normal weight juveniles. DESIGN: RESULTS: ADMA levels are slightly, but significantly increased (p=0.04) in obese (0.78+/-0.01 micromol/l), compared to normal weight juveniles (0.74+/-0.01 micromol/l). There are no robust correlations of ADMA with obesity related disorders, like dyslipidemia, hypertension, low-grade inflammation and pre- atherosclerosis. Age, body length and alkaline phosphatase, as markers of growth are correlated with ADMA. Multiple testing revealed that, alkaline phosphatase turned out as highly significant positively correlated with ADMA in normal weight (r=0.45/p<0.0001) and obese (r=0.59/p<0.0001) children. CONCLUSIONS: We show here, that ADMA is slightly increased in obese juveniles without any robust correlations to obesity related disorders. ADMA is tightly correlated with alkaline phosphatase as a marker of growth in obese and normal weight, healthy juveniles.
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Authors | H-J Gruber, C Mayer, A Meinitzer, G Almer, R Horejsi, R Möller, S Pilz, W März, R Gasser, M Truschnig-Wilders, H Mangge |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 116
Issue 9
Pg. 520-4
(Oct 2008)
ISSN: 0947-7349 [Print] Germany |
PMID | 18523919
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- symmetric dimethylarginine
- N,N-dimethylarginine
- Arginine
- Alkaline Phosphatase
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Topics |
- Adolescent
- Alkaline Phosphatase
(blood)
- Arginine
(analogs & derivatives, blood)
- Atherosclerosis
(physiopathology)
- Blood Pressure
- Body Mass Index
- Child
- Female
- Growth
(physiology)
- Humans
- Male
- Obesity
(complications, physiopathology)
- Reference Values
- Regression Analysis
- Young Adult
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