Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor.

Abstract

ACTH was purified from thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. Amino acid composition and C- and N-terminal analyses indicated that this tumor ACTH was comprised of the 2-38 sequence of authentic pituitary ACTH. The observations suggest that the mode of cleavage of this tumor ACTH from its precursor is different from that of pituitary ACTH.

• Authors: P J Lowry, L H Rees, S Tomlin, G Gillies, J Landon
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 43 Issue 4 Pg. 831-5 (Oct 1976) ISSN: 0021-972X [Print] United States
• PMID: 185233 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amino Acids
• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (biosynthesis, isolation & purification)
• Amino Acids (analysis)
• Carcinoid Tumor (metabolism)
• Humans
• Organ Specificity
• Pituitary Gland (metabolism)
• Thymus Neoplasms (metabolism)