Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report.

Abstract

INTRODUCTION:

Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei.

CASE PRESENTATION:

We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset.

CONCLUSION:

The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative.

• Authors: Felix Gundling, Henning Wittenburg, Andrea Tannapfel, Joachim Mossner
• Journal: Journal of medical case reports (J Med Case Rep) Vol. 2 Pg. 191 (Jun 03 2008) ISSN: 1752-1947 [Print] England
• PMID: 18522718 (Publication Type: Journal Article)