Multidrug resistance-1 in T lymphocytes and natural killer cells of adults with idiopathic thrombocytopenic purpura: effect of prednisone treatment.

Abstract

High P-glycoprotein-mediated multidrug resistance-1 (P-gp/MDR1) activity in lymphocytes from idiopathic thrombocytopenic purpura (ITP) patients may affect disease outcome. ITP treatment includes glucocorticoids that are substrates of P-gp; hence, P-gp functional activity and antigenic expression were assessed by flow cytometry in T and natural killer (NK) cells from ITP patients before and after prednisone therapy. Herein, patients' T and NK cells did not show increased MDR1 functional activity, whereas P-gp antigenic expression was significantly enhanced in both therapy-free and prednisone-treated patients. Prednisone treatment did not significantly modify the function and expression of MDR1 in T and NK cells of ITP patients.

• Authors: Xavier López-Karpovitch, Gerardo Graue, Erick Crespo-Solís, Josefa Piedras
• Journal: Archives of medical research (Arch Med Res) Vol. 39 Issue 5 Pg. 541-5 (Jul 2008) ISSN: 0188-4409 [Print] United States
• PMID: 18514101 (Publication Type: Journal Article)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Prednisone

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics, metabolism)
• Adult
• Drug Resistance, Multiple
• Female
• Humans
• Killer Cells, Natural (drug effects, metabolism)
• Male
• Middle Aged
• Prednisone (pharmacology, therapeutic use)
• Purpura, Thrombocytopenic, Idiopathic (drug therapy, metabolism)
• T-Lymphocytes (drug effects, metabolism)