Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis.

Abstract

Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.

• Authors: Judith M Greer, Michael P Pender
• Journal: Journal of autoimmunity (J Autoimmun) Vol. 31 Issue 3 Pg. 281-7 (Nov 2008) ISSN: 0896-8411 [Print] England
• PMID: 18502611 (Publication Type: Journal Article, Review)

Chemical References

• Autoantigens
• Myelin Proteolipid Protein

Topics

• Animals
• Autoantigens (immunology, metabolism)
• Autoimmunity
• Central Nervous System (immunology, metabolism)
• Encephalomyelitis, Autoimmune, Experimental (etiology, immunology, metabolism)
• Humans
• Multiple Sclerosis (etiology, immunology, metabolism)
• Myelin Proteolipid Protein (immunology, metabolism)