Abstract |
The effect of intratracheal surfactant administration was studied in rats with adult respiratory distress syndrome associated with infection with nebulized Sendai virus. Thirty-six hours after infection, animals (n = 7) showed severely impaired gas exchange and acidosis during artificial ventilation (PaO2 = 152.2 +/- 18.7, PaCO2 = 65.3 +/- 19.2, pH = 7.26 +/- 0.11) with a pressure-controlled mode, standard frequency of 35/min, peak airway pressure of 15 cm H2O (15/0), inspiratory/expiratory ratio of 1:2, and F1O2 = 1. Gas exchange improved (P = 0.02) with increased ventilator pressures with PEEP (25/4). Forty-eight hours after infection, blood gas tensions could no longer be significantly improved by these same ventilator settings (PaO2 = 123.8 +/- 31.0, PaCO2 = 95.1 +/- 43.6, pH = 7.12 +/- 0.16, n = 9). At this time, surfactant replacement dramatically increased arterial oxygenation within 5 min (PaO2 = 389.4 +/- 79.9) and resulted in a fourfold increase in PaO2 within 2 h. It is concluded that intratracheal surfactant administration is a promising approach in the treatment of respiratory failure during adult respiratory distress syndrome associated with viral pneumonia.
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Authors | G J van Daal, K L So, D Gommers, E P Eijking, R B Fiévez, M J Sprenger, D W van Dam, B Lachmann |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 72
Issue 5
Pg. 589-95
(May 1991)
ISSN: 0003-2999 [Print] United States |
PMID | 1850209
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Hydrogen-Ion Concentration
- Lung
(pathology)
- Male
- Parainfluenza Virus 1, Human
- Paramyxoviridae Infections
(complications, pathology)
- Pneumonia, Viral
(complications, physiopathology)
- Pulmonary Gas Exchange
(drug effects)
- Pulmonary Surfactants
(administration & dosage, therapeutic use)
- Rats
- Rats, Inbred Strains
- Respiratory Distress Syndrome
(complications, drug therapy)
- Trachea
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