Abstract | BACKGROUND: METHODS: The antinociceptive effects of these anticonvulsants were examined in the acetic acid writhing test in mice. The side effect propensity of these drugs was examined using the rotarod test. RESULTS:
Carbamazepine (25-60 mg/kg; p.o.), oxcarbazepine (10-40 mg/kg; p.o.), gabapentin (10-70 mg/kg; p.o.), and topiramate (5-30 mg/kg; p.o.) caused a significant dose-dependent reduction the number of writhes in the writhing test. In the rotarod test, carbamazepine (60-140 mg/kg; p.o.) and oxcarbazepine (120-450 mg/kg; p.o.) significantly reduced the time spent on the rotarod in a dose- and time-dependent manner. Gabapentin (1000-2000 mg/kg; p.o.) and topiramate (400-1500 mg/kg; p.o.) did not produce significant impairment of motor performance at the highest doses used. The therapeutic index (motor impairing dose TD(50)/writhing ED(50)) values were topiramate (>148.5) > gabapentin (>60.2) > oxcarbazepine (15.2) > carbamazepine (2.3). CONCLUSIONS:
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Authors | Radica M Stepanovic-Petrovic, Maja A Tomic, Sonja M Vuckovic, Sonja Paranos, Nenad D Ugresic, Milica S Prostran, Slobodan Milovanovic, Bogdan Boskovic |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 106
Issue 6
Pg. 1897-903
(Jun 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18499629
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amines
- Analgesics
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- Topiramate
- Fructose
- Carbamazepine
- gamma-Aminobutyric Acid
- Gabapentin
- Acetic Acid
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Topics |
- Acetic Acid
- Amines
(pharmacology)
- Analgesics
(adverse effects, pharmacology)
- Animals
- Anticonvulsants
(adverse effects, pharmacology)
- Behavior, Animal
(drug effects)
- Carbamazepine
(pharmacology)
- Cyclohexanecarboxylic Acids
(pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Fructose
(analogs & derivatives, pharmacology)
- Gabapentin
- Male
- Mice
- Motor Activity
(drug effects)
- Pain
(chemically induced, physiopathology, prevention & control)
- Pain Measurement
- Rotarod Performance Test
- Time Factors
- Topiramate
- Viscera
(innervation)
- gamma-Aminobutyric Acid
(pharmacology)
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