Abstract | BACKGROUND: METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 +/- 1.8 h) was significantly delayed compared with that in the placebo group (3.1 +/- 0.8 h) (P < 0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION:
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Authors | Michael J Sheen, Shung-Tai Ho, Chian-Her Lee, Yu-Chi Tsung, Fang-Lin Chang |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 106
Issue 6
Pg. 1868-72
(Jun 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18499625
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amines
- Anesthetics, Local
- Antipruritics
- Cyclohexanecarboxylic Acids
- Narcotics
- gamma-Aminobutyric Acid
- Gabapentin
- Morphine
- Bupivacaine
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Topics |
- Adult
- Amines
(administration & dosage)
- Anesthesia, Spinal
- Anesthetics, Local
- Antipruritics
(administration & dosage)
- Bupivacaine
- Cyclohexanecarboxylic Acids
(administration & dosage)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Gabapentin
- Humans
- Injections, Spinal
- Lower Extremity
(surgery)
- Male
- Morphine
(administration & dosage, adverse effects)
- Narcotics
(administration & dosage, adverse effects)
- Orthopedic Procedures
- Premedication
- Prospective Studies
- Pruritus
(chemically induced, prevention & control)
- Severity of Illness Index
- Time Factors
- Treatment Outcome
- gamma-Aminobutyric Acid
(administration & dosage)
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