Abstract | OBJECTIVES: Postgastrectomy iron deficiency anemia has a variable prevalence and occurs in 20-50% of patients. Food fortification reports examining ferrous glycinate chelate have shown that it can be 2.5-3.4 times more bioavailable than ferrous sulfate, with minimal gastrointestinal symptoms. The present study was designed as a controlled experimental study including 18 gastrectomized patients with iron deficiency anemia to compare the effects of ferrous sulfate and ferrous glycinate chelate in the treatment of anemia and to evaluate the presence of side effects. METHODS: Patients were divided in two groups: group 1 received ferrous sulfate (200 mg twice a day, corresponding to 80 mg of elemental iron) and group 2 received ferrous glycinate chelate (250 mg/d, corresponding to 50 mg of elemental iron) for 4 mo. Laboratory measurements were performed at baseline and after 2 and 4 mo. RESULTS: Group 1 showed an apparent recovery in laboratory parameters, with increases in medium corpuscular hemoglobin (P = 0.02), serum iron (P = 0.02), and ferritin (P = 0.04), and a decrease in transferrin (P = 0.002) after 4 mo. Individualized analysis showed that only one patient using ferrous sulfate had anemia at the end of the study in contrast to six patients using ferrous glycinate. In addition, ferritin levels increased above 20 microg/L at the end of the study in seven patients using ferrous sulfate in contrast to one patient using ferrous glycinate. CONCLUSION:
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Authors | Erika C Mayumi Mimura, José Wander Breganó, Jane Bandeira Dichi, Emerson Pereira Gregório, Isaias Dichi |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
2008 Jul-Aug
Vol. 24
Issue 7-8
Pg. 663-8
ISSN: 0899-9007 [Print] United States |
PMID | 18499399
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Ferrous Compounds
- Hemoglobins
- Iron Chelating Agents
- bis-glycino iron II
- ferrous sulfate
- Ferritins
- Iron
- Glycine
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Topics |
- Aged
- Anemia, Iron-Deficiency
(drug therapy)
- Biological Availability
- Female
- Ferritins
(blood)
- Ferrous Compounds
(pharmacokinetics, therapeutic use)
- Gastrectomy
(adverse effects)
- Glycine
(analogs & derivatives, pharmacokinetics, therapeutic use)
- Hemoglobins
(metabolism)
- Humans
- Intestinal Absorption
- Iron
(blood)
- Iron Chelating Agents
(pharmacokinetics, therapeutic use)
- Male
- Middle Aged
- Nutritional Status
- Treatment Outcome
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