Cutaneous infection with Leishmania infantum in an infant treated successfully with miltefosine.

Abstract

A two-year-old girl presented with a 20 month history of a facial nodule which had appeared after a vacation on Mallorca. Various topical treatments at other hospitals for the working diagnosis of mastocytoma failed to prevent a slow increase in size and the onset of systemic signs and symptoms. An indurated crusted nodule evolved. Histology, tissue PCR and serologic analysis proved the presence of Leishmania infantum. She was treated with oral miltefosine 10 mg p.o. t.i.d. for 28 days. Regression was apparent after 8 weeks and complete healing after 6 months.

• Authors: Angela Neub, Dieter Krahl, August Stich, Ulrich Amon
• Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (J Dtsch Dermatol Ges) Vol. 6 Issue 12 Pg. 1061-4 (Dec 2008) ISSN: 1610-0387 [Electronic] Germany
• PMID: 18498377 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Phosphorylcholine
• miltefosine

Topics

• Administration, Topical
• Animals
• Antifungal Agents (administration & dosage)
• Child, Preschool
• Female
• Humans
• Leishmania infantum (drug effects)
• Leishmaniasis, Visceral (diagnosis, drug therapy)
• Phosphorylcholine (administration & dosage, analogs & derivatives)
• Treatment Outcome