Angiofollicular lymph node hyperplasia and peripheral neuropathy. Case report and literature review.

Abstract

A man with multicentric angiofollicular lymph node hyperplasia and a polyclonal gammopathy developed a debilitating sensory-motor peripheral neuropathy that resolved with plasma-pheresis and immunosuppressive therapy. Fourteen similar cases have been reported in the literature; however, to our knowledge, this is the first report of successful treatment with plasma-pheresis. Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive therapy.

• Authors: B Scherokman, S J Vukelja, E May
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 151 Issue 4 Pg. 789-90 (Apr 1991) ISSN: 0003-9926 [Print] United States
• PMID: 1849398 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Azathioprine
• Prednisone

Topics

• Aged
• Azathioprine (therapeutic use)
• Castleman Disease (complications)
• Humans
• Immunosuppression Therapy
• Male
• Peripheral Nervous System Diseases (complications, therapy)
• Plasmapheresis
• Prednisone (therapeutic use)